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Majid Ali, M.D.
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Darwin, Cancer Trials, and Lapdog Joes
Lapdog Joes (In matters of health, reporters for the corporate media nearly always act like lapdogs Joes—my term for journalistic lapdogs—not like watchdogs,) of The New England Journal of Medicine and The New York Times do not understand or are too lazy to investigate crucial issues of ethics and science in conducting clinical trials for chemotherapy drugs for treating cancer.

In Darwin, Dysox, and Disease (2006), the eleventh volume of The Principles and Practice of Integrative Medicine, I defined a principle of science which I designate as the Darwin Principle—a principle of drawing simple conclusions from an extended and integrated study of a large body of observations. The Darwin Principle accepts the validity of each scientific observation concerning any part of the whole but holds that none of them singly be accepted as the definitive evidence of any conclusion about the condition of the whole. The core tenet of the Darwin Principle is: No part can be understood except through an understanding of its relationships with the whole. I consider the Darwin Principle of crucial importance for both understanding the molecular biology of cancer and designing scientifically sound treatment plans.

In 1831, Charles Robert Darwin (1809-1882), started his journey aboard the British Navy ship H.M.S. Beagle around South America. Over a period of five years, he accumulated an enormous number of biologic and geologic samples, studied them intensively, reflected on the interconnectedness of all of them, and formed his simple — yet comprehensive— biological theory of natural selection. In 1850, he published On the Origin of Species which, in my view, is the most significant work in biologic sciences. For individuals interested in the control of cancer, Darwin’s core message is this: No aspect of cancer can be understood except through an understanding of its relationships with the whole. Translation: No treatment plans for cancer which do not address nutritional, environmental, and anger-related issues can be considered scientific.

The clinical application of the Darwin Principle calls for clinical trials which are radically different from the model of chemotherapy drug trials in vogue today. The clinical trials based on the Darwin Principle must be designed to address the macro furies (toxic thoughts, toxic environment, and toxic foods), as well as the three micro furies (oxidosis, acidosis, and dysoxgenosis) of disease. Such investigations can be conducted only as open, integrated trials in which teams of experienced clinicians enter a sizeable number of individuals with well-defined clinicopathologic entities into trials and then are free to address all macro and micro issues on basis of the needs of individual patients. The trial outcome is determined by evaluation of the results by patients as well as clinicians employing objective and subjective criteria. The integrity of an outcome is assured by ensuring that: (1) a sufficiently large number of clinicians participate in the trial who categorically have no financial interest in the outcome; (2) all cancer trials include all patients treated at the center at which those trials are conducted; and (3) all cancer trials are carried out for sufficiently extended periods of study so that the conclusions drawn from the data truly represent long-term results of the trial. In Darwin, Dysox, and Disease (2006), I present a compendium of my philosophic discussion of the Darwin Principle and the results of several long-term clinical outcome studies designed and conducted following the Darwin Principle.

The matter of patients deciding the efficacy of treatment is likely to raise some eyebrows. We have raised generations of doctors who think no clinical trials must be considered valid in which the patients have had anything to say in determining the outcome of the trial. However, who can gauge the quality of sleep or energy — may I ask—better than the patient himself? Or the freedom from toxic thoughts? Or the qualities of mood, memory, and mentation? Or digestive and menstrual health? Or sexual drive? Or absence or presence of dry skin and muscle suppleness? For decades, I have been baffled by hearing otherwise intelligent doctors mindlessly insist that the patient’s voice must be vigorously excluded from clinical trials.

The Aristotle Principle and Nutritional Therapies for Cancer

In my clinical work, I tried to walk in Darwin’s footsteps. However, I recognize that there were others before Darwin, some of whom Darwin credited for his work. Foremost among them was Aristotle. He is the first among empirical scientists. I include here brief comments about the Greek empirical scientist, biologist, embryologist, and philosopher whose work has evident relevance to my clinical work with individuals with cancer.

Aristotle (384-322 BC) was the great empirical scientist of the Greek civilization. He was a biologist who lucidly documented the embryology of chicken. He rejected Plato’s mystical speculation and established the inductive method. In 335 B.C., he founded the Lyceum (library). His most notable scientific achievement, in the present context, was his classification of animals in an ascending scale, reaching all the way to humans. Darwin acknowledged his debt to Aristotle in his work with evolution. Based on his works available today, it is often stated that Aristotle never implied evolution in his classification of animals. That does not seem right to me. How could a man of his towering intellect and astute empiricism have missed that relationship?

Aristotle’s extant works essentially come from the lecture notes taken by his students and edited in the 1st century B.C., and include Organum, De Anima, Discourse on Conduct, Politics, and Ethics. Concerning observable phenomena, Aristotle proposed four principles of explanation of causality of physical phenomena:

✪ The principle of the material (substance of the thing) cause;
✪ The principle of the formal (design) cause;
✪ The principle of the efficient (the maker) cause; and
✪ The principle of the final (purpose) cause.

In the context of cancer, what did Aristotle mean by material (the substance of the thing) except nutrition? What did he mean by the formal (design) except metabolism? What did he mean by the efficient (maker) except the toxic environment? In the context of cancer treatment, what did he mean by the final (purpose) except the desired outcome in cancer treatment? How often do the leaders in the field of oncology ask themselves any of those Aristotolian questions? Do they even remember any of the precepts of Aristotolian empirical science? That brings me to what may be called the “Aristotle Principle.”

The Aristotle Principle is the principle of empiricism in clinical medicine that requires all relevant nutritional, metabolic, and environmental issues must be vigorously addressed with empirically-validated measures in every patient. In cancer treatment, the Aristotlian Principle means the following:

✪ No cancer treatment plan can be considered scientifically valid if it does not address all relevant nutritional issues;
✪ No cancer treatment plan can be considered scientifically valid if it does not address all relevant metabolic issues; and
✪ No cancer treatment plan can be considered scientifically valid if it does not address all relevant environmental issues.

Eco-monsters and onco-monsters relentlessly violate the Aristotelian and Darwinian precepts with devastating consequences. Millions of people with cancer all over the world have—and continue to—suffer immeasurably because onco-monsters do not allow oncologists the use of simple, safe, and effective natural therapies for controlling cancer. The mantra of onco-monsters is that there is no science behind those therapies. In the chapter entitled “Onco-Monsters,” I address that issue and show how pathetically ignorant men and women are who hide behind that mantra.

Medicine Once Was A Calling

Medicine once was a calling. Then it became a profession, then a business, then the big business. No group of people suffered from the transition of medicine from a calling to big business more than the one with cancer.

When medicine was a calling, it attracted women and men with a passion for healing. The practitioners became passionate advocates for their patients. Then some practitioners of medicine wanted prestige. They saw a possibility for that in getting organized, and began calling medicine a profession. In pursuit of seeking control over patients and peers, the organized medicine established standards of practice. In a shameful act of professional misconduct, the leaders in the field of oncology chose to ignore the crucial issues of toxic foods, toxic environment, and toxic thoughts. There are few, if any, oncologists today who vigorously prescribe nutrient therapies, diligently work to remove toxins (toxic acids, metals, and pollutants), and effectively address issues of toxic thoughts.

Next, medicine became an industry. The cancer industry turned out to be the most callous. It gained complete control over oncologists, and relentlessly persecuted practitioners who attempted to address the issues of toxic thoughts, toxic environments, and toxic foods. In the process, the cancer industry enriched itself enormously by an aggressive use of chemo drugs of dubious value merchandised by onco-monsters. Not unexpectedly, those riches did not escape the notice of real men of money in the country. They hired more onco-monsters and took over the oncology industry and converted it into the mega-business of oncology, which owned chemo drugs, insurance companies, medical journals, hospital boards, cancer centers, and doctors who worked in them.

The rising incidences of various types of cancer, most notably the twin pandemics of breast and prostate cancer, have much to teach us about how seriously our environment is disrupting our hormonal functions, and how those environmental exposures are setting the stage for yet higher incidences of various types of cancer. Regrettably, those critical issues are seldom, if ever, addressed in oncology. All the pronouncements of leaders in the field about cancer begin and end with their choice of chemotherapy drugs. Lessons learned through the loss of millions of lives all over the globe continue to be ignored.

The Great Hoax: The “Target” Drugs That Are Not Target Drugs

These are heady times for low-level scientists in the drug industry. They are pregnant with hope of designing “target” drugs that silence individual genes or block single enzymes. They plan to cure cancer with those target drugs. I welcome such drugs for whatever benefit they can give my patients. However, I have no illusions about the promise of the target drugs. First, I know for certain that the so-called target drugs are really not specific for their targets. Second, I do not think there will ever be cures of most types of cancer with the target drugs, since those cancers are not caused by mutations in a few genes or a few enzymes. What we need are integrated treatment protocols that not only employ the old chemotherapy agents and the so-called target drugs (for whatever benefits they yield) but effectively address the essential metabolic derangements encountered in cancer —acidosis (too much acidity), oxidosis (excess free radicals), and dysox (lack of functional oxygen). I discuss those subjects at length in the various chapters of this volume. Here, I include brief comments about the so-called “miracle designer drugs,” which are not miracle drugs by any stretch of imagination, regardless of the spin created by onco-monsters.

The success of Glivec [Gleevec in the United States] in the treatment of chronic myleogenous leukemia (CML) has provided proof of principle that cancer can be treated by identifying molecular defects and designing drugs to correct them. Promising results in trials with other molecularly targeted drugs, such asIressa and Tarceva have given further encouragement for such approaches. (Italics added)

Nature Reviews—
Cancer. 2002;2:645
The Reality

Tarceva [for lung cancer] resulted in an overall response and disease stabilization rate of 48% as monotherapy for patients who had failed previous chemotherapy…Iressa showed a relatively modest 11.8% tumor suppressor rate at the most effective dosing regimen… For example, in certain subsets of patients with CML, 52% did not respond to Glivec, and 78% relapsed within one year.

Nature Reviews—
Cancer. 2002;2:645

What Is Tumor Suppressor Rate?

It is a euphemism for temporary shrinkage of the tumor before the cancer returns with a crushing roar. That is the sad and recurring story known to all people whose family members or friends were treated with chemotherapy. That is sad truth behind the false hopes built with the promise of tumor suppression with “new target drugs” that come around every few years.

Oxygen Thinking and Integrative Cancer Treatment

In oncology, the crucial Darwinian and Aristotolian precepts of holism and integration are consistently violated in the clinical practice of oncology. Why is that so? It is because onco-monsters do not allow oncologists to use nutritional, herbal, detox, and oxygen therapies to protect their patients from the toxicities of their drugs. Why is that so? Because eco-monsters do not see any profits in health preservation, disease prevention, and reversal of disease. This is a harsh indictment of my profession. In this volume, I present my arguments for that harsh treatment. Consider the following quote from the September 2002 issue of Nature Reviews—Cancer (page 637):

…is a seminal work and shows that the local microenvironment is the driving force in stimulating or suppressing the invasive and malignant behaviors of cancer cells.

Nature Reviews —
Cancer. 2002;2:637

The above is an encouraging note sounded by Nature Reviews. Clearly, the journal is promoting an ecologic — read, holistic — approach to understanding and treating cancer. Let us hope that clinicians treating cancer will read it and begin to think ecologically. Since oxygen determines the microenvironmental condition within and around cancerous tumors more than any other single element, let us also hope that soon there will be “oxygen thinking” among physicians caring for individuals with cancer. However, the article quoted above was published four years ago. I still have not seen any willingness to consider and address crucial nutritional, environmental, detox, and oxygen-related issues, which are of crucial clinical importance.

We physicians need to return to our calling. We need to learn something about Aristotle’s empirical science. We need to acquire some Darwinian sense of selective pressure on cellular populations, and the relationships between the parts and the whole. We need to be clear about who eco-monsters are: They are cults of craven men who wantonly and relentlessly destroy human habitat, poison our environment, and unleash pandemics of cancer. We need to know who onco-monsters are: They are people charged by eco-monsters to do their bidding, regardless of the consequences of their actions. They pretend to be great scientists, academics, teachers, editors of journals, and custodians of public health. They are the self-righteous in a cruel cartoon, doing their masters’ bidding. They have no passion for the sick, nor an authentic interest in service to those with cancer. They want leadership but have no concept of service. We physicians need to be aware. Our patients pay an exorbitant price when we fail to do so. Nowhere is that toll harsher and more punishing than when our patients with cancer suffer from the false benevolence of eco-monsters and the pseudoscience of onco-monsters.

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